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Posts Tagged ‘dna’

I’ve been quite fascinated by electric car firm Better Place since I read up on how the company was founded by former SAP executive Shai Agassi in the excellent book ‘Start-up Nation’, which tells of Israel’s historical entrepreneurial DNA and tech success stories.

Basically, Better Place aims to reduce global dependency on petroleum through the creation of a market-based transportation infrastructure that supports electric vehicles, relying on renewable energy from solar arrays and wind farms instead of oil. The startup, founded just 2 years ago, is currently building its first electric vehicle network in Israel, and plans to deploy the infrastructure in other nations on a country-by-country basis with initial deployments beginning this year, and commercial sales beginning in 2012.

As of April 2009, it had already raised $400 million, with several countries offering tax breaks in favor of the ambitious venture. This morning, Better Place announced that it has raised a massive $350 million follow-up venture funding round to lay the groundwork for these deployments, valuing the company at a whopping $1.25 billion.

HSBC led the round with a $125 million capital injection (buying them approx. 10% of the company), with eight other investors participating, including Morgan Stanley Investment Management, Lazard Asset Management, Israel Corp., VantagePoint Venture Partners, Ofer Hi-Tech Holdings and others.

Better Place says it intends to expand into markets where the business model economics and investor returns are “optimized”, citing Europe and Asia specifically. The company also reaffirmed its original target to begin full commercial operations at the end of next year, when industry partner Renault plans to offer the first car with a replaceable battery.

Like with every game not called World of Warcraft , I played Assassin’s Creed II for a solid two or three hours, and it’s been collecting dust ever since then. This is relevant because, what, Ubisoft sold me (and all of you!) an incomplete game

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Assassin’s Creed II DLC priced and dated: Now you can finish the game

PayPal co-founder and Founders Fund Managing Partner Luke Nosek is tackling a new field: DNA sequencing. Nosek sent out an email (which we’ve pasted below) saying that he has joined Halcyon Molecular, a human genome sequencing firm, as founding president.

According to the email, Halcyon will sequence complete human genomes in less than ten minutes and for less than $100. This is significant drop in price and time from existing genome sequencing labs that take weeks and thousands of dollars to process DNA. Nosek writes that he will continue to lead The Founders Fund’s genomics investing, but his primary role will be leading and advising Halcyon as the company progresses and readies for launch. Nosek adds that Peter Thiel, fellow co-founder of PayPal and Managing Partner at Founders Fund will be joining Halcyon’s board.

When Halcyon Molecular finally launches, its pricing and timing could be revolutionary. 23andme, which reads and tests parts of the human genome and was co-founded by Sergey Brin’s wife Anne Wojcicki, is similar in theory. But 23andme doesn’t do a full genome scan, which Halcyon promises to do, but rather looks at SNPs, which are regions of high variability in the human genome.

This summer I joined as Founding President of Halcyon Molecular, an extraordinary company which has developed a technology for sequencing DNA vastly more quickly, completely, accurately, and cheaply than ever. Ultimately, Halcyon will sequence 100% complete human genomes in less than 10 minutes and for less than $100. Current methods, which take weeks, sequence only about 90% of the genome, and cost from tens to hundreds of thousands of dollars depending on completeness.

Because only a handful of human genomes have been sequenced (and none completely), statistically significant insights have been hard to come by. If genetic research doesn’t seemed to have lived up to its therapeutic promise, it’s because sequencing is just too slow and expensive. With Halcyon’s technology, the pool of genetic information will grow by orders of magnitude in the course of months, offering the first real chance at cures for cancer and other previously intractable diseases. With full sequencing and analysis of millions of genomes, biology can begin to turn into an information science and travel down the path of Moore’s law. While we have 10X better computers and video games every ten years, we do not have 10X better cancer cures and we do not really understand what causes the major killer diseases of the first world other than the cop-out term “aging”. We must change this.

Halcyon’s progress has been rapid in the months since I joined. We have:

· Raised significantly more capital than we need
· Hired world leaders in biochemistry, nanofabrication, and electron microscopy
· Expanded our academic collaborations with Harvard, Stanford, and UC Berkeley
· Received a $2 million dollar aberration corrected STEM electron microscope on loan from the Department of Energy

Founders Fund and myself have made a significant bet on this firm, perhaps the most significant since our investment in Facebook. I have joined as President and moved closer to Halcyon’s future offices in Stanford Research Park to work intensively with the team (I maintain my board seats on SpaceX, Pathway Genomics, and continue to lead Founders Fund’s genomics investing as well). Peter Thiel also joined the board to lend his expertise. But ultimately Halcyon needs the greatest scientists and engineers in the world to succeed in its mission. I know that exceptional people are hard to come by, but of all the Founders Fund companies that have, or have the potential to change the world – Facebook, SpaceX, Palantir, e.g. – Halcyon is the one with the chance to do so in the most profound way possible. It is truly vital that it work.

I want to stress that this is the most talented team I have ever worked with. This is not a job for your best friend’s brother-in-law. Halcyon people have put aside and left their homes, their million dollar salaries, full professorships at major universities, and fully seed-funded startup companies to be part of this effort.

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Bing is beginning to find its way onto the iPhone through apps that build on top of its APIs. One that just hit the iTunes Store is an augmented reality app called Robotvision (iTunes link). Like other AR apps, it uses the video camera on the iPhone 3GS, as well as the GPS and the compass to bring up data about nearby restaurants and shops, including reviews. It gets this local business data from Microsoft’s Bing search engine.

Once you find a place nearby, you can call it the business from within the app. A lot of this functionality is already in the current Yelp iPhone app hidden as an Easter Egg, but Robotvision has some nice extra features. For instance, a feature is triggered by looking down at the screen, which shows the business and others like it as pins on a map. You can toggle back and forth between augmented reality view and map view depending on how the phone is positioned. (see video demo below).

Robotvision also shows you nearby Tweets and geo-tagged Flickr photos. I’m not sure how useful these are in an augmented-reality app. Basically, these are best suited for surfacing information about a place directly in your view or right around the corner. There are plenty of Twitter apps, like Twinkle, that show you nearby Tweets. For the most part these are pretty useless unless they are people you know. I guess it would be cool to be able to point your phone’s camera to a crowd and see related Tweets from people in that crowd, but Robotvision isn’t quite that advanced yet.

Last month, Microsoft announced its Bing iPhone SDK, which this app is using.

Here is a video demo recorded last month:

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Fitness gadget Fitbit was a hit at last year’s TechCrunch50, where it created a ton of buzz and was a runner-up for the top prize. Of course, we all know that it takes hardware companies longer to launch than software startups and since last September, Fitbit has been working tirelessly to refine the product, establish distributions channels and tweak its online platform. Now we won’t have to wait any longer, since Fitbit will officially open up to the public on Tuesday. The site you see currently is the beta version and will feature a redesign as well on Tuesday.

So what does Fitbit do? The sleek little device clips onto your clothing and tracks your movement, sleep and calorie burn throughout the day and night. Fitbit, which costs $99, uses the information it gathers about your movement to help you determine how much exercise you’ve been getting and how many calories you’ve burnt. It can also tell you how many steps you have taken and how well you’ve slept, all based on its internal motion detector. By clicking a little button on the device, you’ll see a small blue LED screen that will alternate between the steps you’ve taken, the calories you’ve burned, your distance, and gives you a gauge of how high your activity level is. This is shown via a small flower that will grow as you exercise more (though I’m told that you will be able to switch your icon).

Here’s the really innovative part—the device is wireless so all data gets automatically synchronized to your computer and then the web through a wireless base station, so you don’t even have to plug it in. If you are within 10 feet of the device (it plugs into your computer via a USB cord), the station will sync with your device. In order for the wireless functionality to work you need to install a syncing software that runs on both Macs and PCs. Once synced, you can view your health dashboard online.

The dashboard is fairly simple and organized. You input your age, height, weight, and gender and are given basic info of how many steps you’ve made in a day and a breakdown of how active you are within the day, showing the highs and lows of your activity. The site will even break down particular activities and measure the intensity of workout. In terms of caloric burn and intake, Fitbit will calculate how many calories you burn in a given day, and if you log in your nutritional info, will also compare that to how much your intake was, making it ideal for anyone who wants to lose weight. And Fitbit has made it easy to input any type of food by already integrating the nutritional value of most types of food, cuisine and even restaurant chain foods, which cuts out a large amount of work for you.

One of the features that I find particularly compelling is the ability to monitor your sleep pattern. If you wear the device while sleeping, it will give you a snapshot of your “sleep health.” As you fall in and out of sleep, the Fitbit tracks the movements that your body makes and can tell you how long it took you to fall asleep, how many times you woke up throughout the night and the actual time you were asleep vs the time you were in bed. You will be able to see all of this detailed information on your dashboard. And to make sure that the device is comfortable for people to wear during the night, you can slide Fitbit onto a wristband that is provided.

Fitbit’s co-founder and CEO, James Park, told me that when it comes to running and walking, Fitbit is 99 percent accurate in its reporting of steps and 90 percent accurate for caloric burn. But Fitbit isn’t as accurate for other types of activities, like weight-lifting and biking. To mitigate this problem, the online dashboard lets you input exercise types and times manually and Fitbit will calculate how many calories you burned based on health information it has collected.

On Tuesday, the site will be open to the public and all of those individuals who pre-ordered the device over the past year will finally receive their Fitbit. While the site will be the only place you can order the Fitbit, Park says that in Q4 you’ll be able to buy the Fitbit online and in retail stores but declined to name which stores he’s partnered with. Fitbit raised a cool $2 million last October and Park says they are looking to raise more to up manufacturing and distribution channels.

Fitbit will also become more social, letting users form groups where they can compare their fitness goals and activities. The site will also take a page out of Mint.com’s book by letting you compare your activity and fitness with other anonymous people who have similar weight, height, and gender. While using the personalized dashboard is free, Fitbit will soon be rolling out premium paid features such as customized fitness coaching and guidance.

So what’s the competition? There are similar products on the market that offer the same functionality as Fitbit, such as the Philips Activity Monitor or the BodyBugg or Nike/iPod gear (which doesn’t measure sleep patterns). But the beauty of fitbit is in it’s pricing and in its sleek structure. It fits in any pocket and is so small and unobtrusive that it could be hooked into a bra. Both the Philips and BodyBugg products are bulky, making it difficult to wear 24-hours per day. The advantage of the BodyBugg is that it measures calories burn by heat, which is a more efficient and accurate way of measuring calorie burn. Fitbit counts calories via motion, but that’s also why it’s easy to wear.

I wasn’t at TechCrunch50 last year but after seeing a demo, I’m already excited about this product after being frustrated with the limitations of pedometers that I’ve used. The ability to wirelessly connect to the online dashboard takes a lot of the work out of actually making sense of the data. And being able to understand your optimal balance of diet, workouts and sleep is valuable. It seems that Fitbit was worth the wait.

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Linda Avey, one of the two founders of personal genomics company 23andMe, is leaving the startup to start a new foundation dedicated to studying Alzheimer’s disease. Avey, who has been with the company for over three years, writes that the new foundation will make use of 23andMe’s research platform to “drive the formation of the world’s largest community of individuals with a family history of Alzheimer’s, empower them with their genetic information and track their brain health using state-of-the-art tools”.

Avey notes that the foundation will be starting with the connection between Alzheimer’s and ApoE4, which helps in the breakdown of peptide plaques associated with the disease. The decision seems to be driven in part by personal reasons, as Avey’s father-in-law suffered from Alzheimer’s.

Avey sent the following Email to the 23andMe team:

Dear all-

As I trust you all know, 23andMe is very special to me. I also recognize that the company has reached a critical point in its growth where new leadership can take it to the successful heights we all think it can achieve.

I’ve decided that I’d like to focus my efforts on an area that is personally significant and will continue to have a huge impact on our healthcare system–Alzheimer’s disease. Effective today, I’m leaving 23andMe and have begun making plans for the creation of a foundation dedicated to the study of this disorder. The foundation will leverage the research platform we’ve built at 23andMe–the goal is to drive the formation of the world’s largest community of individuals with a family history of Alzheimer’s, empower them with their genetic information and track their brain health using state-of-the-art tools. We’ve always planned to include Alzheimer’s in our 23andWe research mission…I’m just approaching it from a new angle.

Some of you might be aware that my father-in-law suffered from Alzheimer’s and passed away last year. For this reason, Randy and I are motivated to do what we can to improve the understanding of what leads to the debilitating symptoms and what might prevent them from starting in the first place. The ApoE4 association is barely understood but gives us a great starting point.

I’ll miss working with you but will be excited to hear about the progress I know you’ll be making!

All the best,
Linda

Anne Wojcicki, who founded the company with Avey and is also noted for being Sergey Brin’s wife, sent out the following letter.

Team:

As Linda has told you, she will be leaving 23andMe to focus her energy on transforming Alzheimer’s research and treatment, leveraging the 23andMe platform. While I am quite sad to see her leave I am excited and hopeful as she takes on this mission. As Linda’s co-founder and partner over the last three years, it has been clear that revolutionizing research has been a primary passion. Our drive to change health care has always had roots in our personal lives and we have tried to structure 23andMe so that any individual or organization could actively participate in research. Linda and I have talked about doing research in Alzheimer’s since the inception of the company and the need for the Alzheimer’s community to have a strong leader. With Linda’s involvement, I believe that the APOE4 community could be the first asymptomatic community to successfully develop preventative treatments. I hope that going forward we’ll both be able to shake up and transform the health care space, making health care and treatments better for all.

Linda’s departure is also a sign of 23andMe’s maturation. When we started the company, the personal genetics industry did not exist; now it is a thriving and competitive landscape. Our company has grown and we continue to be an innovative industry leader. While our success has been exceptional, it is also clear we have a lot of work ahead. We have created a significant and empowering tool, but we must find new and better ways to promote the value of knowing your DNA. In the weeks ahead, we will outline a strategy for the company that we believe will make genetics a routine part of health care and will lead us to making significant research discoveries.

Linda has been instrumental in making 23andMe what it is today and we thank her for her passion and dedication to the company. We have many exciting opportunities before us, and I look forward to working with all of you to make 23andMe a spectacular success.

Anne

Worth pointing out is Wojcicki’s statement that 23andMe needs to find “better ways to promote the value of knowing your DNA”. That may be tricky — while there are some traits that are well understood, this is a field that is still in its infancy and the relationships between our genes and most traits are murky. At some point personal genomics will play a key role in our health care system, but I’m not sure we’re there yet.

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The CEA represents the CE industry and runs CES. The CE industry likes to make and ship thing but it doesn’t like to recycle them.

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CEA members don’t like carting away garbage, try to beat NYC recycling laws

Sony held a bit of a rah-rah song-and-dance event in the UK yesterday that revealed a few more details about the company’s motion controller. It was absolute mustard

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PlayStation Eye software will be able to detect gender of players

What the hell, WB? I want Scribblenauts and I want it now! Eurogamer has confirmed with Warner Bros.

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Scribblenauts for the DS gets dated for the UK

Dell is currently offering a brand new Xbox 360 Pro (60GB) for $250, which is $50 cheaper than it normally goes for. Geeks.com has refurbed 360 Elites for $230 with a 90-day warranty Xbox 360 Elite System w/120GB HDD, HDMI Port, Wireless Controller & Headset [Geeks] Xbox 360 Pro 60GB [Dell]

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CrunchDeals: Xbox 360 Pro for $250, refurb Elite for $230